Intestinal and hepatic extraction (%) of VER calculated according to approach 1 and 2 before or after (+Keto) treatment with ketoconazole
Values are presented as mean and S.D.
| Substance | EG | +Keto | EH | +Keto |
|---|---|---|---|---|
| R-VER | ||||
| Approach 1 | 77 ± 4 | 50 ± 9a | ||
| 48 ± 34b | ||||
| Approach 2 | 61 ± 17 | 47 ± 10 | 49 ± 21 | 65 ± 20 |
| S-VER | ||||
| Approach 1 | 86 ± 2 | 61 ± 6a | ||
| 61 ± 34b | ||||
| Approach 2 | 74 ± 13 | 55 ± 15 | 68 ± 13 | 80 ± 11 |