Pharmacokinetic parameters of SV after i.v. (1 mg/kg) or p.o. (20 mg/kg) administration of SV with a concomitant oral dose of vehicle or KTZ (20 mg/kg)
Each value represents the mean ± S.D. of four monkeys.
i.v. (1 mg/kg SV) | p.o (20 mg/kg SV) | |||||
|---|---|---|---|---|---|---|
| + Vehicle | + KTZ (20 mg/kg) | + Vehicle | + KTZ (20 mg/kg) | |||
| Cmax (ng/ml) | 7.9 ± 6.1 | 104.9 ± 86.3 | ||||
| Tmax (h) | 5.0 ± 2.6 | 4.0 ± 2.3 | ||||
| t1/2 (h) | 2.1 ± 0.8 | 1.9 ± 0.6 | 4.8 ± 2.9 | |||
| CLtot (ml/h/kg) | 1288 ± 110 | 1309 ± 110 | ||||
| Vdss (ml/kg) | 2567 ± 245 | 2770 ± 507 | ||||
| AUC (h · ng/ml) | 773 ± 64 | 762 ± 68 | 120 ± 95 | 587 ± 343* | ||
| F (%) | 0.8 ± 0.6 | 3.8 ± 2.1* | ||||
| FH (%) | 52 ± 4 | 52 ± 4 | ||||
| FABS · FG (%) | 1.6 ± 1.3 | 7.5 ± 4.2 | ||||
| Ratios (KTZ/Vehicle) | ||||||
| Cmax | 12.9 ± 4.6 | |||||
| AUC | 1 ± 0.1 | 6.3 ± 2.6 | ||||
| F | 6.3 ± 2.6 | |||||
| FH | 1 ± 0.1 | |||||
| FABS · FG |
|
|
| 6.6 ± 2.8 | ||
↵* p < 0.05, compared with the values in the monkeys coadministered with vehicle for KTZ.