i.v. (1 mg/kg SV) | p.o. (20 mg/kg SV) | |||||
---|---|---|---|---|---|---|
+ Vehicle | + KTZ (20 mg/kg) | + Vehicle | + KTZ (20 mg/kg) | |||
Cmax (ng/ml) | 144.9 ± 10.2 | 128.9 ± 11.4 | 2.9 ± 0.5 | 20.9 ± 8.1* | ||
Tmax (h) | 0.083 ± 0.000 | 0.125 ± 0.084 | 1.5 ± 0.6 | 4.0 ± 2.3 | ||
t1/2 (h) | 1.4 ± 0.2 | 1.5 ± 0.2 | 6.3 ± 7.0 | |||
AUC (h · ng/ml) | 284 ± 24 | 288 ± 19 | 26 ± 14 | 130 ± 31** | ||
Ratios (KTZ/vehicle) | ||||||
Cmax | 0.9 ± 0.1 | 7.2 ± 2.5 | ||||
AUC |
| 1.0 ± 0.1 |
| 6.0 ± 3.0 |