Pharmacokinetic parameters of KTZ after p.o. (20 mg/kg) administration of KTZ with i.v. or p.o. coadministration of SV
Each value represents the mean ± S.D. of four monkeys.
p.o. (20 mg/kg KTZ) | |||
|---|---|---|---|
| + SV (1 mg/kg i.v.) | + SV (20 mg/kg p.o.) | ||
| Cmax (ng/ml) | 719 ± 637 | 621 ± 569 | |
| Tmax (h) | 2.5 ± 1.0 | 3.5 ± 1.9 | |
| t1/2 (h) | 4.6 ± 0.7 | 3.0 ± 0.6 | |
| AUC (h · ng/ml) | 1710 ± 1325 | 2167 ± 814 | |