Model estimated pharmacokinetic parameters of atomoxetine
Parameter | Estimate (% SEE) | Inter-Rat Variability (% SEE) |
|---|---|---|
| CL (liter/h) | 14.5 (8.69) | 38.6 (23.7) |
| V (liter) | 6.92 (30.8) | 65.4 (80.1) |
| QBCB (l/h) | 0.0000909 (29.9) | |
| QBBB (l/h) | 0.00110 (34.5) | |
| CLECF-CSF (l/h) | 0.000129 (20.2) | |
| CLECF-BC (l/h) | 0.00216 (25.1) | |
| CLBC-ECF (l/h) | 0.000934 (25.7) | |
| VBC (liters) | 0.000990 (fixed) | |
| VCSF (liters) | 0.000250 (fixed) | |
| VECF (liters) | 0.000290 (fixed) | |
| σprop | 34.7 (9.09) |
|
% SEE, percentage S.E. of the estimate; σprop, proportional residual error.