Competitive inhibition constant, Ki, estimated from 3- and 10-min incubation in rCYP3A (+b5) and HLMs using competitive inhibition model
Data are presented as mean ± S.D.
rCYP3A4 (+b5) | HLMs | |||||
|---|---|---|---|---|---|---|
| 3 min | 10 min | 3 min | 10 min | |||
| ERY | 55 ± 13 | 14.3 ± 4 | 73 ± 18 | 29 ± 19.8 | ||
| nd-ERY | 67 ± 11 | 8.2 ± 2.3 | 77 ± 12 | 19.8 ± 12.2 | ||
| DTZ | 5.9 ± 2.1 | 2.8 ± 0.5 | 41 ± 9 | 5.1 ± 3.1 | ||
| nd-DTZ | 0.6 ± 0.09 | 0.09 ± 0.2 | 0.8 ± 0.1 | 0.6 ± 0.24 | ||