TABLE 3

The %ME and %MAE estimated for eqs. X and Y for the prediction of the extent of CYP3A inhibition in the presence of multiple inhibitors in rCYP3A4 (+b5) and HLMs

Data are presented as mean ± S.D.

%ME
%MAE
Eq. X
Eq. Y
P
 Eq. X
Eq. Y
P
rCYP3A4 (+b5)
    ERY + DTZ -0.03 ± 0.06 0.01 ± 0.06 <0.001 0.05 ± 0.04 0.04 ± 0.04 0.4
    ERY + nd-ERY -0.04 ± 0.04 -0.01 ± 0.05 <0.001 0.05 ± 0.03 0.03 ± 0.22 0.22
    DTZ + nd-DTZ -0.10 ± 0.10 -0.06 ± 0.08 <0.001 0.15 ± 0.10 0.09 ± 0.06 <0.05
    All four compounds 0.03 ± 0.05 0.01 ± 0.07 <0.001 0.11 ± 0.09 0.08 ± 0.12 0.12
HLMs
    ERY + DTZ -0.03 ± 0.06 0.01 ± 0.05 <0.01 0.05 ± 0.05 0.04 ± 0.03 0.25
    ERY + nd-ERY -0.10 ± 0.07 -0.03 ± 0.06 <0.01 0.10 ± 0.07 0.05 ± 0.04 <0.05
    DTZ + nd-DTZ -0.08 ± 0.08 -0.02 ± 0.06 <0.01 0.09 ± 0.07 0.03 ± 0.03 0.02
    All four compounds
-0.11 ± 0.09
0.04 ± 0.05
<0.01
0.11 ± 0.05
0.06 ± 0.05
0.88