Bidirectional transport of LY354740 and LY544344 across MDCKII-MDR1 cell monolayers in the absence and presence of a P-gp inhibitor (LSN335984)
Transport of LY354740 and LY544344 across MDCKII-WT cell monolayers resulted in similar permeability values (data not shown).
Compound | Papp a | Efflux Ratio | ||
|---|---|---|---|---|
| A-to-B | B-to-A | |||
| × 106 cm/s | ||||
| LY354740 | 1.3 | 1.3 | 1.0 | |
| +LSN335984 | 1.6 | 1.1 | 0.7 | |
| LY544344 | 1.3 | 1.3 | 1.0 | |
| +LSN335984 | 1.3 | 0.9 | 0.7 | |
↵ a Mean Papp (n = 2).