Percentage metabolism of Type I and Type II pyrethroids by rat P450 isoforms
Isoform | Bifenthrin | S-Bioallethrin | Bioresmethrin | β-Cyfluthrin | λ-Cyhalothrin | Cypermethrin | cis-Permethrin | trans-Permethrin | Resmethrin |
|---|---|---|---|---|---|---|---|---|---|
| CYP1A1 | 38.7 ± 3.1a | 25.7 ± 1.5 | 66.3 ± 3.1 | 61.3 ± 0.6 | 64.7 ± 3.5 | 68.3 ± 1.2 | 47 ± 8 | 58.3 ± 7.5 | 81 ± 1.7 |
| CYP1A2 | 8.7 ± 2.5 | N.S. | 31.3 ± 5.1 | N.S. | N.S. | 12 ± 2.6 | 12.3 ± 4.5 | 38.3 ± 7.5 | 29 ± 11.5 |
| CYP2A1 | N.S.b | 11.3 ± 3.5 | N.S. | 15.3 ± 3.5 | N.S. | 22.6 ± 2.5 | N.S. | N.S. | 20.3 ± 2.9 |
| CYP2B1 | 14.3 ± 4.7 | N.S. | N.S. | N.S. | N.S. | 13 ± 2.6 | N.S. | N.S. | N.S. |
| CYP2C6 | 88.7 ± 2.1 | 95 ± 1 | 97.7 ± 2.3 | 50 ± 2.6 | 39 ± 2.6 | 55.7 ± 2.9 | 83.7 ± 5 | 88.7 ± 2.1 | 91 ± 1.7 |
| CYP2C11 | 68.7 ± 5.8 | 97.3 ± 0.6 | 94.3 ± 2.5 | N.S. | 58.3 ± 7.5 | 79.7 ± 4.2 | 77.7 ± 15.9 | 82 ± 5.3 | 89.3 ± 0.6 |
| CYP2C12 | 12.7 ± 3.2 | N.S. | N.S. | 14.7 ± 1.5 | N.S. | N.S. | N.S. | N.S. | N.S. |
| CYP2C13 | N.S. | N.S. | N.S. | N.S. | N.S. | N.S. | N.S. | N.S. | 12.7 ± 0.6 |
| CYP2D1 | N.S. | N.S. | N.S. | 15.7 ± 5.1 | 42.3 ± 1.5 | 12.3 ± 4.6 | N.S. | N.S. | N.S. |
| CYP2D2 | N.S. | N.S. | 4 ± 1 | N.S. | N.S. | 11 ± 4.4 | N.S. | N.S. | 11 ± 2 |
| CYP3A1 | 40.7 ± 8.3 | 81.7 ± 0.6 | 45 ± 7 | 46.3 ± 10.4 | 70.7 ± 5.9 | 59.7 ± 9.3 | 30.3 ± 5.5 | N.S. | 51.3 ± 1.5 |
| CYP3A2 | 30.3 ± 4.5 | 56.3 ± 3.8 | 33 ± 9 | 24.3 ± 2.5 | 38.3 ± 3.5 | 26.7 ± 7.2 | 16.7 ± 1.2 | 13.3 ± 3.5 | 29.7 ± 5.9 |
N.S., no significant difference.
↵ a Percentage parent pyrethroid metabolized during a 10-min incubation; mean ± S.D., n = 3.
↵ b The percentage metabolism of pyrethroids by rat P450s was assessed by a one-sample t test. Values that were not significantly different from 0 were labeled N.S. (p < 0.05).