TABLE 1

Tmax, Cmax, and AUC0–168 h values for 14C in blood after single oral administration of [dichlorophenyl-14C]pyridalyl to male and female rats at 5 (low dose) and 500 (high dose) mg/kg

Data are the mean values ± S.D. for three animals.

TmaxCmaxAUC0–168 h
hppmμg Eq, h/g
Male
    Low dose2.00 ± 0.0000.31 ± 0.0634.21 ± 0.602
    High dose7.33 ± 4.61918.4 ± 3.89402.4 ± 98.25
Female
    Low dose2.00 ± 0.0000.40 ± 0.0824.63 ± 1.365
    High dose10.00 ± 0.00022.7 ± 4.27477.5 ± 147.88