Summary of the study design
Four different treatments were included in the study. Rosuvastatin was administered alone as an intrajejunal and as an intravenous dose in TI and TIV, respectively. In TII and TIII, the intrajejunal dose of rosuvastatin was accompanied with either cyclosporine (TII) or gemfibrozil (TIII).
| n | Investigational Drugs | Dose and Drug Administration Site | ||
|---|---|---|---|---|
| Rosuvastatin | Coadministrant | |||
| TI | 6 | Rosuvastatin | 80 mg i.j. | |
| TII | 6 | Rosuvastatin + Cyclosporine | 80 mg i.j. | 300 mg CVC infusion (2 h) |
| TIII | 6 | Rosuvastatin + Gemfibrozil | 80 mg i.j. | 600 mg i.j. |
| TIV | 4 | Rosuvastatin | 5.9 mg i.v. | |
n, number of animals; CVC, central vein catheter.