Absolute concentrations of the nonhydroxylated metabolites detected after multiple administration (day 1-day 2-day 3) of AD in six chimeric mice (Chim1–Chim6)
No data were available for Diol 3 or DHEA.
| hAlb | Concentrations (n = 3) | |||||||
|---|---|---|---|---|---|---|---|---|
| T | EpiT | E | A | DHT | AD | Diol 1 | Diol 2 | |
| ng/ml ± RSD% | ||||||||
| Chim1, 0.4 mg/ml | ||||||||
| Day 1 | 270.7 ± 9.4 | 37.9 ± 1.9 | 451.4 ± 5.4 | 370.4 ± 4.1 | 42.1 ± 0.6 | 52.8 ± 10.1 | ||
| Day 2 | 432.0 ± 2.3 | 45.7 ± 5.6 | 590.5 ± 0.9 | 480.3 ± 1.7 | 50.4 ± 3.9 | 54.5 ± 1.0 | ||
| Day 3 | 26.8 ± 5.5 | 21.7 ± 1.5 | 376.3 ± 3.9 | 139.5 ± 12.6 | 13.6 ± 17.7 | 10.0 ± 13.2 | ||
| Chim2, 0.5 mg/ml | ||||||||
| Day 1 | 348.5 ± 3.4 | 54.8 ± 3.0 | 336.6 ± 4.2 | 228.6 ± 4.0 | 44.8 ± 9.2 | 18.7 ± 13.3 | 53.2 ± 6.7 | |
| Day 2 | 411.8 ± 11.3 | 65.5 ± 4.4 | 341.1 ± 5.4 | 215.7 ± 8.8 | 64.5 ± 4.6 | 22.8 ± 1.4 | 50.2 ± 9.5 | |
| Day 3 | 254.6 ± 6.3 | 42.3 ± 5.2 | 215.8 ± 5.6 | 106.1 ± 9.5 | 28.9 ± 3.9 | 18.1 ± 3.7 | 25.2 ± 4.3 | |
| Chim3, 1.1 mg/ml | ||||||||
| Day 1 | 1183.8 ± 3.9 | 112.5 ± 8.1 | 1360.2 ± 6.7 | 1534.6 ± 1.6 | 168.9 ± 8.0 | 321.0 ± 0.5 | 202.9 ± 8.1 | |
| Day 2 | 321.0 ± 3.2 | 85.8 ± 7.2 | 873.5 ± 2.5 | 769.1 ± 5.1 | 43.2 ± 9.6 | 93.0 ± 3.9 | 97.0 ± 4.2 | |
| Day 3 | 395.2 ± 1.5 | 130.1 ± 7.1 | 1291.4 ± 2.0 | 885.8 ± 1.4 | 66.4 ± 6.0 | 77.2 ± 7.0 | 122.0 ± 5.2 | |
| Chim4, 2.0 mg/ml | ||||||||
| Day 1 | 193.4 ± 3.9 | 1739.8 ± 13.7 | 8368.8 ± 9.7 | 1115.7 ± 15.5 | 16.0 ± 4.0 | 168.4 ± 12.3 | 66.1 ± 5.6 | |
| Day 2 | 34.7 ± 5.1 | 712.7 ± 6.4 | 2701.7 ± 12.9 | 237.3 ± 4.7 | 4.4 ± 88.6 | 62.3 ± 14.2 | 69.3 ± 8.8 | |
| Day 3 | 51.3 ± 0.5 | 1007.3 ± 17.8 | 3156.7 ± 2.3 | 342.8 ± 6.8 | 11.8 ± 14.3 | 76.8 ± 6.3 | 92.8 ± 3.6 | |
| Chim5, 2.7 mg/ml | ||||||||
| Day 1 | 233.5 ± 3.6 | 129.0 ± 7.6 | 2509.4 ± 4.8 | 3412.1 ± 4.1 | 12.1 ± 18.4 | 115.2 ± 7.2 | 55.2 ± 12.8 | |
| Day 2 | 119.4 ± 0.6 | 112.2 ± 4.3 | 3803.6 ± 0.7 | 2669.3 ± 1.4 | 13.8 ± 23.8 | 206.5 ± 4.0 | 54.5 ± 1.2 | |
| Day 3 | 276.9 ± 1.6 | 122.8 ± 2.1 | 2142.6 ± 5.4 | 2641.6 ± 5.3 | 98.5 ± 4.5 | 91.9 ± 8.3 | ||
| Chim6, 4.5 mg/ml | ||||||||
| Day 1 | 67.9 ± 4.9 | 183.9 ± 2.8 | 2800.8 ± 3.1 | 4917.2 ± 2.3 | 41.8 ± 10.0 | 19.2 ± 6.8 | 85.7 ± 2.2 | 113.0 ± 8.4 |
| Day 2 | 69.5 ± 0.7 | 123.9 ± 10.7 | 1933.4 ± 0.8 | 1890.9 ± 2.1 | 132.1 ± 10.4 | 48.2 ± 1.9 | 56.4 ± 9.2 | 36.2 ± 6.7 |
| Day 3 | 69.3 ± 2.5 | 172.1 ± 3.2 | 2729.4 ± 3.3 | 3814.3 ± 2.8 | 38.7 ± 10.8 | 43.9 ± 1.5 | 78.9 ± 2.0 | 71.1 ± 2.6 |
T, testosterone; EpiT, epitestosterone; E, etiocholanolone; A, androsterone; Diol 1, 5β-androstane-3α,17β-diol; Diol 2, 5α-androstane-3α,17β-diol; Diol 3, 5α-androstane-3β,17β-diol.