Pharmacokinetic parameters
| Parameter | Units | [125I]HIR MAb-GDNF | [3H]hIgG1 | [125I]GDNF |
|---|---|---|---|---|
| A1 | %ID/ml | 0.213 ± 0.060 | 0.214 ± 0.008 | 0.049 ± 0.027 |
| A2 | %ID/ml | 0.072 ± 0.016 | 0.173 ± 0.008 | |
| k1 | min−1 | 0.254 ± 0.131 | 0.082 ± 0.007 | 0.020 ± 0.013 |
| k2 | min−1 | 0.0062 ± 0.0030 | 0.0037 ± 0.0004 | |
| MRT | min | 151 ± 79 | 253 ± 41 | 50.0 ± 32.9 |
| Vc | ml/kg | 49 ± 11 | 56 ± 1 | |
| Vss | ml/kg | 168 ± 38 | 112 ± 5 | 446 ± 254 |
| AUC|120 | %ID min/ml | 7.0 ± 0.6 | 25.3 ± 0.3 | |
| AUCss | %ID min/ml | 12.5 ± 4.1 | 48.9 ± 5.4 | 2.44 ± 0.85 |
| CL | ml/min/kg | 1.11 ± 0.34 | 0.45 ± 0.04 | 8.9 ± 1.6 |
A1 and A2, intercepts; k1 and k2, slopes; MRT, median residence time; Vc, central volume of distribution; Vss, steady-state volume of distribution; CL, systemic clearance.