Parameters | Control | Coadministered | Treatment |
---|---|---|---|
4-OH MDZ | |||
AUC0-∞ (μg/l·min) | 38,001 ± 3613 | 69,105 ± 8276* | 93,161 ± 6524* |
Cmax (μg/l) | 614.3 ± 57.2 | 841.3 ± 10.5* | 1111.0 ± 76.9* |
Tmax (min) | 15.0 ± 5.8 | 15.0 ± 5.8 | 20.0 ± 0.0 |
1-OH MDZ | |||
AUC0-∞ (μg/l·min) | 22,916 ± 3203 | 28,538 ± 4216 | 38,349 ± 11,636* |
Cmax (μg/l) | 410.8 ± 40.9 | 384.4 ± 22.0 | 668.2 ± 137.5* |
Tmax (min) | 12.5 ± 5.0 | 20.0 ± 0.0 | 17.5 ± 9.6 |
MDZ | |||
AUC0-∞ (μg/l·min) | 99,410 ± 13,185 | 62,494 ± 4307* | 33,744 ± 6999* |
Cmax (μg/l) | 1822.6 ± 234.1 | 1263.4 ± 47.4** | 786.5 ± 241.0* |
Tmax (min) | 15.0 ± 5.8 | 12.5 ± 5.0 | 17.5 ± 5.0 |
CL/F (l/min/kg) | 0.20 ± 0.03 | 0.32 ± 0.02 | 0.61 ± 0.14* |
↵One-way analysis of variance with post hoc test was conducted, and statistically significant differences (* P < 0.01 and ** P < 0.05) from control group were shown by the asterisks.