TABLE 1

Kinetic parameters for human AO metabolism of 6-substituted quinazolinones

R =	K_M^{^a}	V_max^{^b}	V/K^{^c}	KIE^{^d}
	μM	nmol/s/mg enzyme
OCH₃	293	135	461	N.D.
CH₃	142	22	155	7.6
H	399	240	601	6.3
Cl	27	113	4185	4.5

N.D., not determined.
↵a The concentration at half-maximal velocity. Errors are approximately 10% for each value.
↵b The maximum velocity estimated from the asymptote for the hyperbola. Errors are approximately 10% for each value.
↵c V/K multiplied by 1000.
↵d The isotope effect on V/K determined by taking the ratio of V/K for the proton/deuterium substitution at the site of oxidation.