Pharmacokinetic parameters of MDZ and its metabolites in rats with intragastric administration of MDZ after short-term administration of SLE (n = 4)
| Parameters | Control | SLE (50 mg/kg) | SLE (150 mg/kg) |
|---|---|---|---|
| 4-OH MDZ | |||
| AUC0-∞ (μg/l·min) | 99,951.6 ± 28,610.3 | 63,713.4 ± 12,439.5 | 44,117.2 ± 17,997.5* |
| Cmax (μg/l) | 2436.3 ± 302.3 | 977.9 ± 105.5* | 571.8 ± 228.9* |
| Tmax (min) | 12.5 ± 5.0 | 21.0 ± 8.2 | 26.3 ± 7.5 |
| 1-OH MDZ | |||
| AUC0-∞ (μg/l·min) | 86,071.9 ± 27,782.7 | 60,611.5 ± 17,600.9 | 45,954.2 ± 19,214.0** |
| Cmax (μg/l) | 1882.0 ± 761.9 | 962.5 ± 61.6** | 607.5 ± 262.0** |
| Tmax (min) | 12.5 ± 5.0 | 24.0 ± 8.2 | 26.3 ± 7.5 |
| MDZ | |||
| AUC0-∞ (μg/l·min) | 99,855.0 ± 17,681.6 | 229,001.4 ± 43,349.9* | 400,312.0 ± 29,768.9* |
| Cmax (μg/l) | 2400.8 ± 852.9 | 3799.6 ± 711.2* | 5439.7 ± 204.5* |
| Tmax (min) | 10.0 ± 5.8 | 15.0 ± 0.0 | 15.0 ± 0.0 |
| CL/F (l/min/kg) | 0.2062 ± 0.0442 | 0.0897 ± 0.0159** | 0.0502 ± 0.0037** |
↵One-way analysis of variance with post hoc test was conducted, and statistically significant differences (* P < 0.01 and ** P < 0.05) from control group were shown by the asterisks.