TABLE 1

Effect of dose volume on the toxicokinetics of AA and its metabolites, GA and AAMA, after i.p. administration at 50 mg/kg

AA
GA
AAMA
Dose Volume
5 ml
50 ml
p Value
5 ml
50 ml
p Value
5 ml
50 ml
p Value
AUC (mM/h) 1.31 ± 0.07 1.62 ± 0.05 0.0006a 0.308 ± 0.018 0.152 ± 0.007 <0.0001 0.268 ± 0.021 0.181 ± 0.009 0.0002
Cmax (mM) 0.868 ± 0.032 0.664 ± 0.037 <0.0001 0.069 ± 0.005 0.032 ± 0.001 <0.0001 0.047 ± 0.004 0.026 ± 0.001 <0.0001
Tmax (h) 0.25 ± 0.08 0.50 ± 0.04 <0.0001 2.00 ± 0.00 4.00 ± 0.00 <0.0001 1.00 ± 1.29 4.00 ± 1.36 <0.0001
MRT (h)
1.35 ± 0.04
1.91 ± 0.04
<0.0001
3.06 ± 0.12
4.22 ± 0.15
<0.0001
3.67 ± 0.07
4.11 ± 0.15
0.009

  • ↵ a p Values compare 5 ml to 50 ml and are two-sided.