TABLE 1

Relationship between the metabolic activity and the genotype frequency among four rat strains using PCR-RFLP analysis

The data of the metabolic activity were cited from Sakai et al. (2005).



Total

Genotype (Frequency)

Activity, Diazepam p-Hydroxylation

Wild Homozygote
Heterozygote
Mutant Homozygote
pmol/min/mg protein
SD 9 9 (100%) 0 0 171.9 ± 3.0*
BN 9 9 (100%) 0 0 156.4 ± 8.3*
DA 8 0 0 8 (100%) 0.4 ± 0.0
PM-W 33 0 0 33 (100%) 0.5 ± 0.0
EM-W
8
0
8 (100%)
0
94.6 ± 16.0*
  • * Significant difference from PM-W rats (P < 0.01).