TABLE 4

Fold difference and fm_UGT estimates obtained for 10 drugs obtained in the presence of BSA using individual P450 and UGT cofactors

Compound	-Fold Difference: Cl_{int, u} + BSA/CL_{int, u} - BSA			In Vitro fm_UGT + BSA^a	In Vivo fm_UGT^b
Compound		P450	UGT	In Vitro fm_UGT + BSA^a	In Vivo fm_UGT^b
Buprenorphine	0.7	0.9	0.44	0.50
Carvedilol	1.1	7.9	0.50	N.A.
Codeine	0.8	3.2	0.81	0.82
Diclofenac	4.1	4.7	0.65	N.A.
Gemfibrozil	7.4	12.1	0.86	0.40
Ketoprofen	1.8	4.5	0.71	0.90
Midazolam	3.7	N.D.	N.D.	N.A.
Naloxone	0.6	2.6	0.89	0.65
Raloxifene	15.7	5.4	0.44	N.A.
Zidovudine	0.8	4.8	0.78	0.85

N.D., data not obtained in vitro; N.A., fm_UGT was not available from renal excretion data.
↵ a In vitro fm_UGT was calculated using eq. 5. The fm_UGT estimate obtained in the absence of BSA is shown in Table 1.
↵ b In vivo fm_UGT values were estimated from renal excretion data.