Formation of a second glucuronide of deferiprone
Percentage of all glucuronides represented by the second glucuronide formed in preparations of tissue samples and HEK293-expressed UGT isoforms. K22 to K29 represent liver samples from individual donors.
Sample | Unknown Glucuronide vs. Total Glucuronides Present (100%) |
|---|---|
| % | |
| Tissue samples | |
| Liver K22 | 7.4 |
| Liver K23 | 7.9 |
| Liver K24 | 5.0 |
| Liver K25 | 4.1 |
| Liver K26 | 6.5 |
| Liver K27 | 5.9 |
| Liver K28 | 5.3 |
| Liver K29 | 7.1 |
| Liver pool | 4.4 |
| Kidney | 5.5 |
| Jejunum | 6.7 |
| Ileum | 5.2 |
| HEK293-expressed UGT isoforms | |
| UGT1A6 | 7.0 |
| UGT1A8 | 85.9 |
| UGT1A9 | 41.4 |
| UGT1A10 | 65.7 |