Wild-Type | Fxr-Null | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cont | Chol | CA | CA+Chol | Cont | Chol | CA | CA+Chol | |||||||
Liver bile acid (nmol/g liver) | 157 ± 42 | 72 ± 68 | 424 ± 98a | 490 ± 38a | 580 ± 350 | 485 ± 305 | 2687 ± 646a | 1313 ± 374a,b | ||||||
Liver cholesterol (mg/g liver) | 2.72 ± 0.32 | 2.66 ± 0.46 | 3.86 ± 0.95 | 9.10 ± 2.16a,b | 2.83 ± 0.41 | 6.14 ± 0.71a | 4.97 ± 0.90a | 14.1 ± 5.10a,b | ||||||
Plasma cholesterol (mg/dl) | 75 ± 5 | 57 ± 6 | 69 ± 18 | 58 ± 20 | 111 ± 9 | 97 ± 14 | 110 ± 14 | 160 ± 16a,b | ||||||
ALT (IU/l) | 8 ± 1 | 12 ± 2 | 103 ± 53a | 183 ± 63a | 38 ± 7 | 30 ± 15 | 509 ± 159a | 103 ± 63a,b | ||||||
ALP (IU/l) | 29 ± 4 | 30 ± 5 | 40 ± 9 | 33 ± 10 | 60 ± 11 | 52 ± 2 | 602 ± 103a | 291 ± 60a,b |