TABLE 3

Total fraction excreted (f_{e, Total}; eq. 6) by the ablated transport pathway in each animal model and the corresponding experimentally observed fold change in hepatic metabolite concentration in animal models lacking various transporter proteins

Positive fold Δ values indicate an increase in exposure, whereas decreased exposure is denoted by a negative fold Δ value. All data points were calculated using mean values reported in the literature (Takenaka et al., 1995; Xiong et al., 2002; Nezasa et al., 2006; Zamek-Gliszczynski et al., 2006b,c). Hepatic concentrations were not quantified for carboxydichlorofluorescein (Nezasa et al., 2006) and were not reported for E3040 sulfate and E3040 glucuronide (Takenaka et al., 1995).