Inhibition of hOCT1-, hOCT2-, or hOCT3-mediated [3H]MPP+ uptake by pentamidine and furamidine in the respective hOCT-expressing CHO cells
Inhibitor | hOCT1 IC50 | hOCT2 IC50 | hOCT3 IC50 |
|---|---|---|---|
| μM | μM | μM | |
| Quinidine | 5.7 ± 0.9 | 13.3 ± 0.7 | 22.7 ± 1.9 |
| Pentamidine | 16.4 ± 1.7 | 10.6 ± 2.4 | 14.8 ± 3.4 |
| Furamidine | 7.4 ± 0.9 | 182.0 ± 30.3 | 20.4 ± 2.8 |
| TEA | 469.7 ± 12.7 | 189.2 ± 11.2 | 1476.6 ± 160.1 |