Pharmacokinetic parameters of AZT after a single oral dose of phosphonate1, AZT H-phosphonate, or AZT itself at doses equivalent to 20 mg of AZT/kg in dogs (n = 6)
For designations, see Table 4. Data are presented as the mean ± S.E. (P < 0.001, compared with compound 1).
Administrated Compound | Pharmacokinetic Parameters of AZT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cmax | Tmax | AUC | t1/2 | MRT | CL | ||||||
| mg/l | h | mg · h/l | h | h | l/h | ||||||
| 1 | 0.74 ± 0.03 | 5.0 | 9.2 ± 0.2 | 9.6 ± 0.2 | 13.9 ± 0.2 | 27.0 ± 2.6 | |||||
| AZT H-phosphonate | 1.89 ± 0.07 | 4.0 | 16.6 ± 0.3 | 7.2 ± 0.3 | 10.4 ± 0.5 | 15.0 ± 0.7 | |||||
| AZT | 9.77 ± 0.30 | 2.5 | 58.8 ± 1.1 | 5.2 ± 0.5 | 7.5 ± 0.4 | 4.2 ± 0.3 | |||||
***, P < 0.001.