Pharmacokinetic parameters of phosphonate1and AZT after intragastric administration of1in rabbits (n = 9) at a dose of 70 mg/kg b.wt.
For designaitons, see Table 4. Data are presented as mean ± S.E. (P < 0.001 compared with compound 1).
Compound | Cmax | Tmax | AUC | t1/2 | MRT | CL |
|---|---|---|---|---|---|---|
| mg/l | h | mg · h/l | h | h | l/h | |
| 1 | 2.96 ± 0.09 | 0.5 | 26.92 ± 2.44 | 25.6 ± 3.6 | 34.56 ± 4.03 | 9.3 ± 1.5 |
| AZT | 0.95 ± 0.01 | 2.0 | 4.80 ± 0.37 | 5.2 ± 0.4 | 8.21 ± 1.1 | 52.1 ± 3.7 |