M1 to parent AUC ratios on days 1 and 7 after daily oral dosing with AMG 487 25, 100, and 250 mg for 7 days
AMG 487 | M1/AMG 487 AUC(0-24 h) ratio | ||
|---|---|---|---|
| Day 1 | Day 7 | ||
| 25 (n = 8) | 4.4 ± 2.7 (1.5-9.5) | 3.0 ± 1.8 (0.9-6.6) | |
| 100 (n = 4) | 4.0 ± 2.2 (2.2-7.2) | 1.7 ± 1.1 (0.67-3.0) | |
| 250 (n = 5) | 2.1 ± 0.51 (1.2-2.5) | 0.73 ± 0.34 (0.30-1.3) | |