Species, Dose, and Route | Amount Excreted | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Urine | Feces | Total Radioactivity: 0—lasta | |||||||||||
Radioactivity | Parent: 0—lasta | Radioactivity | Parent: 0—lasta | ||||||||||
0-24 h | 0—lasta | 0-24 h | 0—lasta | ||||||||||
% of dose | |||||||||||||
Rat | |||||||||||||
100 mg/kg i.v. (n = 3) | 41.6 ± 4.37 | 47.6 ± 3.46 | 21.3b | 23.2 ± 7.17 | 32.2 ± 3.32 | 19.7b | 80.9 ± 6.70 | ||||||
100 mg/kg p.o. (n = 3) | 36.5 ± 3.71 | 40.7 ± 5.80 | 15.5b | 45.0 ± 6.77 | 57.3 ± 4.13 | 40.5b | 100 ± 8.55 | ||||||
Dog | |||||||||||||
3 mg/kg i.v. (n = 2) | 66.4c | 72.4c | 18.9b | 1.08c | 6.74c | —d | 83.5c | ||||||
6 mg/kg p.o. (n = 3) | 58.4 ± 6.09 | 69 ± 0.98 | 13.6b | 4.96 ± 7.68 | 11.3 ± 4.19 | 0.13b | 88.4 ± 6.37 |