Plasma AUC% of vildagliptin and circulating metabolites after an oral radiolabeled dose in rat and dog
Bold type indicates major metabolites.
Metabolite | AUC% of Vildagliptin and Circulating Metabolites | ||
|---|---|---|---|
| Rat (100 mg/kg) | Dog (6 mg/kg) | ||
| M14.2 | —a | 2.74 | |
| M14.9 | —a | —a | |
| M15.3 | —a | 26.3 | |
| M16.7 | —a | 2.90 | |
| M17.7 | —a | 3.11 | |
| M20.9 | —a | 2.21 | |
| M20.2 | 5.98 | 1.41 | |
| M20.7 | 53.9 | 33.0 | |
| M21.6 | —a | 1.32 | |
| Vildagliptin |
31.7
|
22.8
| |
↵ a —, not detected.