Metabolites of vildagliptin in feces after an oral radiolabeled dose in rat and dog
Bold type indicates major metabolites.
Metabolite | Rat (100 mg/kg): 0-96 ha | Dog (6 mg/kg): 0-168 h |
|---|---|---|
| M14.2 | —b | 0.12 |
| M14.9 | 1.5 | —b |
| M15.3 | 1.0 | 0.64 |
| M16.7 | 0.7 | 0.13 |
| M1 | —b | —b |
| M17.4 | —b | 0.70 |
| M17.7 | —b | 0.47 |
| M18.6 | 1.5 | —b |
| M20.9 | —b | 1.52 |
| M20.2 | —b | 0.05 |
| M20.7 | 6.4 | 2.25 |
| M21.6 | —b | 0.13 |
| Vildagliptin |
40.5
| 0.31 |