Peak | Retention Time | [M + H]+ | MS/MS Fragment Ionsa | Additional Analysis | Metabolite Identity |
---|---|---|---|---|---|
M1a | 17.6 | 578 | 402, 384, 332, 267 | — | Acyl glucuronide of voreloxin |
M1b | 19.2 | 578 | 402, 384, 332, 267 | — | Acyl glucuronide of voreloxin |
M1 | 20.5 | 578 | 402, 384, 332, 267 | Cleavage w/ β-glucuronidase, OH- | Acyl glucuronide of voreloxin |
M2 | 26.6 | 404 | 360, 318, 307, 297, 247, 243, 217, 205 | — | Dihydro-voreloxin |
M3 | 29.5 | 388 | 370, 318, 269, 243 | Chemical standard | O-Desmethyl-voreloxin |
M2a | 34.4 | 360 | 318, 307, 302, 297, 369, 260, 247, 243, 217, 205, 193 | Chemical standard | Dihydrodecarboxylic acid voreloxin |
M4 | 38.7 | 388 | 370, 318, 269, 243 | Chemical standard | N-Desmethyl-voreloxin |
Voreloxin | 39.5 | 402 | 384, 332, 269, 243, 231 | Parent drug | Voreloxin |
M5 | 49.9 | N.D. | — | — | Unknown |
—, not performed; N.D., not determined.
↵ a Major fragment ions are indicated in bold.