Summary of kinetic parameters for the concentration-dependent uptake of [14C]YM155 into PC-3, Calu-6, NCI-H358, A375, SK-MEL-5, RL, and Ramos cells
Data are expressed as estimate ± S.E.
Cell Line | Km | Vmax | Pdif | ||||
|---|---|---|---|---|---|---|---|
| μM | pmol/min/mg protein | pmol/min/106 cells | μl/min/mg protein | μl/min/106 cells | |||
| PC-3 | 0.243 ± 0.015 | 14.93 ± 0.48 | 0.484 ± 0.033 | ||||
| Calu-6 | 0.189 ± 0.020 | 4.58 ± 0.25 | 0.718 ± 0.036 | ||||
| NCI-H358 | 0.254 ± 0.033 | 3.40 ± 0.25 | 0.432 ± 0.027 | ||||
| A375 | 0.367 ± 0.042 | 6.87 ± 0.50 | 0.711 ± 0.048 | ||||
| SK-MEL-5 | 0.359 ± 0.057 | 4.01 ± 0.41 | 0.607 ± 0.047 | ||||
| RL | 0.202 ± 0.008 | 2.56 ± 0.06 | 0.117 ± 0.008 | ||||
| Ramos | 0.283 ± 0.029 |
| 0.980 ± 0.059 |
| 0.0788 ± 0.0042 | ||