Ludi scores, theoretical Ki values (micromolar; Ludi score = -100 log Ki), and mean experimental Ki values (micromolar) for inhibition of CYP2C9-mediated diclofenac 4′-hydroxylase by flavonols and flavones in the RECO CYP2C9 system
Compound | Ludi Score | Theoretical Ki | Experimental Ki (RECO CYP2C9) |
|---|---|---|---|
| 6-Hydroxyflavone | 563a | 2.34a | 2.2a |
| Quercetin | 578 | 1.66 | 2.0 |
| Luteolin | 587 | 1.35 | 1.3 |
| Baicalein | 596 | 1.10 | 0.9 |
| Apigenin | 640 | 0.398 | 2.0 |
| Morin | 641 | 0.389 | 1.8 |
↵ a Noncompetitive inhibition; in all other situations, competitive inhibition.