Transporter | TNF-α | IL-6 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
mRNA | Protein | Activity | mRNA | Protein | Activity | |||||
MDR1 | ↔b | ↔ | N.D.c | ↓d | ↔ | N.D. | ||||
BSEP | ↓ | N.D. | N.D. | ↔ | N.D. | N.D. | ||||
MRP2 | ↔ | ↔ | N.D. | ↓ | ↓ | N.D. | ||||
MRP3 | ↔ | ↑e | N.D. | ↔ | ↑ | N.D. | ||||
MRP4 | ↔ | N.D. | N.D. | ↔ | N.D. | N.D. | ||||
BCRP | ↔ | ↑ | N.D. | ↓ | ↓ | N.D. | ||||
NTCP | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ||||
OATP2B1 | ↓ | N.D. | ↓f | ↓ | N.D. | ↓f | ||||
OATP1B1 | ↓ | ↓ | ↓f | ↓ | ↓ | ↓f | ||||
OATP1B3 | ↓ | N.D. | ↓f | ↓ | N.D. | ↓f | ||||
OCT1 | ↓ | N.D. | ↓ | ↓ | N.D. | ↓ | ||||
OAT2 | ↓ | N.D. | N.D. | ↓ | N.D. | N.D. |
↵ a Human hepatocytes were exposed to cytokines for 48 h.
↵ b ↔, no change.
↵ c N.D., not done.
↵ d ↓, significant repression.
↵ e ↑, significant induction.
↵ f Activity was measured used the pan-OATP substrate estrone-3 sulfate and therefore may not reflect specific OATP2B1-, OATP1B1-, or OATP1B3-mediated transport.