TABLE 4

Average SUVincrease and Kp,increase over 60 min in cerebellum, striatum, and frontal cortex after CsA administration

[11C]Verapamil
[11C]GR205171
[18F]Altanserin
SUVincrease
Kp,increase
SUVincrease
Kp,increase
SUVincrease
Kp,increase
Cerebellum
    Rat 4.1* 5.8** 3.6** 3.5** 2.6*a 2.3*a
    Rat low dose CsA 1.4ns 1.5**
    Guinea pig 3.9*** 2.9** 2.3** 2.0ns
    Minipigb 1.8 0.8
    Monkeyb 4.3 3.6 2.1 2.5
High binding regionc
    Rat 2.6*a 2.9*a
    Minipigb 2.0 0.9
    Monkeyb
2.6
2.9

  • ↵* P < 0.05, ** P < 0.01, and *** P < 0.001, compared with baseline values.

  • ↵ a Ex vivo studies; values at 60 min after radiotracer administration.

  • ↵ b A single animal received CsA.

  • ↵ c High binding region: striatum for [11C]GR205171 and frontal cortex for [18F]altanserin.