TABLE 2

Physiological and biochemical parameters of isolated vascular perfused segments of human intestine during predose and 15, 30, 45, 60, and 75 min after administration of antipyrine (21 μmol), terbutaline (20 μmol), and mannitol (21 μmol) or Texas Red dextran (5 mg) (group 1)

Data are mean ± S.E.M.

Parameters
Mean Predose Values
Change at Each Time Point (n = 6)
15 min
30 min
45 min
60 min
75 min
% % % % %
Perfusion pressure 38 ± 5.8 mm Hg 89.3 ± 3.7 75.5 ± 2.4* 69.7 ± 6.6* 65.9 ± 6.7* 64.3 ± 6.4*
Perfusion flow 59 ± 6 ml/min 100 ± 0.0 101 ± 1.2 101 ± 1.2 101 ± 1.2 101 ± 1.2
Temperature 35.9 ± 0.3°C 101 ± 1.2 101 ± 1.4 100 ± 1.6 102 ± 0.9 101 ± 0.9
Hematocrit 16.5 ± 0.7% 99.8 ± 2.6 93.8 ± 3.4 96.1 ± 2.0 96.1 ± 2.9 95.2 ± 3.1
pH 7.4 ± 0.1 100 ± 0.2 101 ± 0.4 101 ± 0.5* 102 ± 0.6* 102 ± 0.7*
Glucose 115.3 ± 2.6 mg/dl 97 ± 2.3 95 ± 3.5 91 ± 3.6* 86 ± 3.7* 79 ± 2.8*
Lactate 6.4 ± 0.9 mmol/l 114 ± 4.5 137 ± 11* 153 ± 15* 166 ± 18* 172 ± 16*
K+ 6.1 ± 1.1 mmol/l 102 ± 0.9 104 ± 1.1* 107 ± 2.3* 110 ± 2.2* 111 ± 1.9*
Amylase
20.5 ± 7.4 U/l
N/A
159 ± 19*
N/A
186 ± 19*
N/A

  • N/A, not analyzed.

  • ↵* p < 0.05 vs. predose (100%).