[3H]FLB-457 binding in rat striatal membranes
Test compounds displaced [3H]FLB-457 from rat striatal membranes in a monophasic manner to yield pKi values ranging from 6.7 to 8.6. Data represent mean ± S.E.M. from n = 3 experiments.
Compound | pKi |
|---|---|
| Chlorpromazine | 8.4 ± 0.1 |
| Clozapine | 6.8 ± 0.2 |
| Haloperidol | 8.6 ± 0.1 |
| Quetiapine | 6.7 ± 0.1 |
| Risperidone | 8.4 ± 0.1 |
| Ziprasidone | 8.6 ± 0.1 |