TABLE 3

AUC for each major metabolite

Analyte
AUCa
5 mg/kg
25 mg/kg
125 mg/kg
250 mg/kg
μM-h μM-h μM-h μM-h
ATR 0.68 0.54 2.0 9.6
DE 0.92 2.0 10 38
DIP 1.1 2.5 13 58
DACTb
18 (7.5)
140 (4.8)
750 (35)
1250 (42)

  • ↵ a Obtained from the 0- to 24-h plasma concentration data using the trapezoid function in SigmaPlot (Systat Software, Inc., San Jose, CA).

  • ↵ b Estimated plasma half-lives (h) for DACT are indicated by values in parentheses: data were estimated from the 0- to 24-h time period (Fig. 2B).