The -fold difference of use of the unbound brain concentration measured by brain homogenate method (Cub), CSF concentration (CCSF), and unbound plasma concentration (Cup) to predict the unbound brain interstitial concentration measured by brain microdialysis (Cm) of the nine compounds
Compound | Cub vs. Cma | CCSF vs. Cma | Cup vs. Cma |
|---|---|---|---|
| Carbamazepine | (2) | 1 | 1 |
| Citalopram | 1 | 1 | 1 |
| Ganciclovir | 2 | 1 | 14 |
| Metoclopramide | 1 | 1 | 3 |
| N-Desmethylclozapine | 1 | 1 | 6 |
| Quinidine | (3) | 2 | 6 |
| Risperidone | (2) | 2 | 2 |
| 9-OH-Risperidone | (2) | 5 | 9 |
| Thiopental | (4) | 1 | 1 |
↵ a Concentrations used in the calculations were the values at 6 h after starting intravenous infusion. The reported number represents the -fold difference determined by the ratios of mean values rounded to the nearest whole number. Numbers in parentheses represent -fold underpredictions.