Concentration of modulators causing maximal potentiation of E217βG transport in the assays used
Modular Concentration/Maximal Effect | |||||||
|---|---|---|---|---|---|---|---|
| MRP2 VT | Rat Mrp2 VT | MRP2 Sandwich | Rat Mrp2 Sandwich | ||||
| μM/% of control | |||||||
| Indomethacin | 100/750 | 270/510 | 10/220 | 100/325 | |||
| Probenecid | 330/265 | 1100/280 | 50/158 | 100/130 | |||
| Benzbromarone | 10/430 | 11/155 | 1/182 | 10/155 | |||
| Sulfasalazine | 35/430 | 110/360 | 10/250 | 10/170 | |||
VT, vesicular transport.