TABLE 2

Excretion of total radioactivity in urine and feces

Data were obtained from healthy male subjects receiving a 400-mg single oral dose of [14C]darunavir either alone or with ritonavir (100 mg b.i.d.). Values are mean ± S.D. (n = 4).

Matrix
Collection Interval
Dose Recovered
Darunavir (Unboosted)
Darunavir/Ritonavir (Boosted)
h %
Urine 0-4 4.66 ± 1.39 5.78 ± 0.93
4-9 2.01 ± 0.57 1.74 ± 0.73
9-24 2.32 ± 0.29 2.87 ± 0.58
24-48 1.95 ± 0.44 2.39 ± 0.43
48-72 0.83 ± 0.17 0.75 ± 0.20
72-96 0.38 ± 0.11 0.30 ± 0.06
96-120 0.28 0.24
120-144 N.D. N.D.
144-168 N.D. N.D.
0-168 12.22 ± 2.82 13.93 ± 2.73
Feces 0-168
    MeOH extract 68.31 ± 7.04 67.35 ± 7.72
    Residue 13.37 ± 3.16 12.19 ± 0.73
    MeOH extract + residue 81.68 ± 8.57 79.54 ± 8.10
Urine and feces
0-168
93.90 ± 8.62
93.47 ± 6.40

  • N.D., not detected.