Metabolite | Dose Radioactivity | ||||||
---|---|---|---|---|---|---|---|
Urine | Feces | ||||||
Darunavir (Unboosted) | Darunavir/Ritonavir (Boosted) | Darunavir (Unboosted) | Darunavir/Ritonavir (Boosted) | ||||
% | |||||||
6 | 1.02 ± 0.22 | N.D. | 4.38 ± 0.40 | N.D. | |||
11 | 0.45 ± 0.18 | N.D. | N.D. | N.D. | |||
15 | 3.62 ± 1.05 | N.D. | |||||
15 + 17 + 18 | 0.98 ± 0.40 | ||||||
17 + 18 + 19 | 1.57 ± 0.76 | ||||||
19 | 0.56 ± 0.15 | 2.14 ± 0.56 | 0.67 ± 0.37 | ||||
20 | 0.12 ± 0.06 | 0.66 ± 0.25 | N.D. | N.D. | |||
33 | N.D. | N.D. | 1.60 ± 0.25 | 1.70 ± 0.67 | |||
23 | 0.47 ± 0.29 | 0.25 ± 0.04 | 3.92 ± 0.88 | 2.01 ± 0.25 | |||
29 | 0.28 ± 0.15 | 0.42 ± 0.05 | 4.17 ± 1.46 | 1.00 ± 0.24 | |||
UD | 1.15 ± 0.40 | 7.65 ± 1.74 | 6.83 ± 2.95 | 41.16 ± 1.17 | |||
Unidentified metabolites | 2.59 ± 0.87 | 1.14 ± 0.16 | 19.86 ± 2.86 | 7.25 ± 0.95 | |||
Sum | 7.62 ± 2.47 | 11.69 ± 2.48 | 46.52 ± 3.10 | 53.79 ± 1.39 |
N.D., not detected; UD, unchanged drug.