TABLE 1
Structure and antiviral activity of integrase inhibitors
Compound Number | Structure | Spread CIC95a |
|---|---|---|
| μM | ||
| 1 |
| 0.074 |
| 2 (Raltegravir) |
| 0.031 |
| 3 |
| 0.014 |
| 4 |
| 0.032 |
| 5 |
| 0.061 |
| 6 |
| 0.069 |
| 7 |
| 0.044 |
| 8 |
| 0.107 |
| 9 |
| 0.040 |
| 10 |
| 0.026 |
-
↵ a Cell culture inhibitory concentrations (CIC95) are defined as those that inhibited by ≥95% the spread of HIV-1 infection in susceptible cell culture MT-4 human T-lymphoid cells in the presence of 50% normal human serum (Zhuang et al., 2003).