TABLE 3

Mean prediction errors over the entire simulation time ranges


Tissue

Pure Matrine (15 mg/kg)

ACAPHA (0.38 g/kg)

ACAPHA (3.8 g/kg)a
Adipose -19.0 -42.4 -14.5
Kidney -0.7 -39.9 6.5
Spleen -59.9b -13.9 -11.7
Liver -34.6 -33.8 -25.5
Brain -28.6 -10.8 -31.6
Heart -36.6 30.4 -45.3
Plasma -1.5 16.5 -21.6
Muscle -7.2 8.7 26.9
Lung
-57.0b
-35.2
-14.9
  • a Matrine equivalent dose was 15 mg/kg.

  • b Mean prediction error absolute value >50%.