TABLE 4

Normalized sensitivity coefficients for matrine concentrations in the lung and the plasma

Parametersa
Postdosing Time
2 h
4 h
6 h
8 h
10 h
12 h
High (>0.5)
    CL -0.93 (-0.62)b -0.85 (-0.56) -0.60 (-0.40) -0.37 (-0.25) -0.22 (-0.15) -0.12 (-0.08)
    BLPLR 0.00 (-0.86) 0.00 (-0.40) 0.00 (-0.19) 0.00 (-0.09) 0.00 (-0.04) 0.00 (-0.02)
    F 1.00 (0.86) 0.61 (0.41) 0.29 (0.19) 0.14 (0.09) 0.06 (0.04) 0.03 (0.02)
Medium
    ka -0.14 (-0.09) -0.06 (-0.04) -0.03 (-0.02) -0.01 (-0.01) -0.01 (-0.00) -0.00 (-0.00)
Low (<0.05)
    EH -0.01 (-0.01) -0.01 (-0.01) -0.01 (-0.00) -0.00 (-0.00) -0.00 (-0.00) -0.00 (-0.00)
    tlag 0.05 (0.03) 0.02 (0.02) 0.01 (0.01) 0.01 (0.00) 0.00 (0.00) 0.00 (0.00)
    kf
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)

  • ↵ a For explanation on abbreviations of the parameters, see Table 2.

  • ↵ b Numbers without parentheses are sensitivity coefficients of the lung, and numbers in parentheses are sensitivity coefficients of the blood.