Dose recovered (%) at 24 h after final dose following a single or five serial daily oral administrations of [14C]NBuPy-Cl (50 mg/kg/day) to male F-344 rats
Data are presented as mean ± S.E.M.
Dose Recovered | |||
|---|---|---|---|
| One Administration, n = 4 | Five Administrations, n = 4 | ||
| % | % | ||
| Feces | 45.5 ± 1.7 | 41.4 ± 1.0 | |
| Urine | 43.6 ± 2.0 | 54.0 ± 2.2 | |
| Blood | <0.05 | <0.05 | |
| Tissues | 2.4 ± 0.1 | 0.9 ± 0.1 | |
| Gastrointestinal contents | 1.8 ± 0.3 | 0.3 ± 0.1 | |
| Total recovery | 93.3 ± 0.4 | 96.6 ± 0.7 | |