Concentration in nanomoles per gram of [14C]NBuPy-Cl equivalents in selected tissues (except blood, which was given in nmol/ml) at 24 h after a single oral administration or 24 h after the fifth daily oral administration of [14C]NBuPy-Cl (50 mg/kg/day) to male F-344 rats
Data are presented as mean ± S.E.M.
NBuPy-Cl | |||
|---|---|---|---|
| One Administration, n = 4 | Five Administrations, n = 4 | ||
| nmol/g | nmol/g | ||
| Adipose | 3.6 ± 0.7 | 3.5 ± 0.4 | |
| Blood (nmol/ml) | 0.8 ± 0.1 | 3.2 ± 0.1* | |
| Brain | 0.5 ± 0.1 | 1.5 ± 0.3* | |
| Gastrointestinal tract tissues | 10.0 ± 1.0 | 20.9 ± 3.5* | |
| Kidney | 3.5 ± 0.3 | 7.7 ± 0.2* | |
| Liver | 5.1 ± 0.3 | 10.7 ± 0.2* | |
| Muscle | 10.1 ± 0.4 | 17.9 ± 1.1* | |
| Skin | 4.7 ± 0.8 | 10.5 ± 0.6* | |
↵* p < 0.05 compared with single dose.