Kinetic parameters of NBuPy-Cl and inulin in male F-344 rats after intravenous administration
AUC | t1/2α | t1/2β | CL | Vss | |
|---|---|---|---|---|---|
| μg · min/ml | h | h | ml/min | ml | |
| NBuPy-ClS | 119 | 0.22 | 2.2 | 7.0 | 789 |
| NBuPy-ClC | 121 | 0.21 | 2.7 | 8.5 | 972 |
| InulinC | 97 | 0.28 | 3.4 | 2.8 | 148 |
S, kinetics in blood following a single dose of [14C]NBuPy-Cl (5 mg/kg, 100 μCi/kg); C, kinetics in plasma following coadministration of [14C]NBuPy-Cl (5 mg/kg, 50 μCi/kg) and [3H]inulin (0.67 mg/kg, 250 μCi/kg); CL, systemic clearance.