Excretion of total radioactivity after single administration of [14C]rivaroxaban to rats, dogs, and humans
Species | Route | Sample Collection Time | Radioactivity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urine | Bile | Feces | Cage Wash | Recovery | |||||||
| days | % dose | ||||||||||
| Rat | p.o.a | 7 | 24.7 | 66.9 | 91.6 | ||||||
| Rat | i.v.b | 1 | 30.3 | 48.4 | 12.9 | 91.6 | |||||
| Dog | p.o. | 7 | 52.2 | 42.8 | 2.0 | 97.0 | |||||
| Human | p.o. | 7 | 65.7 |
| 28.0 |
| 93.7 | ||||