Sample | Species | Time | Route | %Dose in Time Interval | Radioactivity | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rivaroxaban | M-1 | M-2 | M-4 | M-5 | M-6 | M-7 | M-8/M-9 | Totala | |||||||||||||
days | % dose | ||||||||||||||||||||
Urine | Rat | 0-2 | p.o.b | 23.5 | 5.2 | 9.1 | 4.1 | 3.2 | 0.1 | 0.7 | 22.4 | ||||||||||
Rat | 0-1 | i.v.c | 30.3 | 8.1 | 11.9 | 3.4 | 5.4 | 1.0 | 29.8 | ||||||||||||
Dog | 0-5 | p.o. | 52.0 | 7.9 | 8.5 | 7.8 | 15.7 | 0.6 | 0.5 | 0.9 | 1.9 | 43.8 | |||||||||
Human | 0-2 | p.o. | 65.4 | 36.2 | 13.1 | 0.7 | 7.6 | 0.9 | 0.3 | 3.7 | 2.1 | 64.6 | |||||||||
Bile | Rat | 0-1 | i.v.c | 48.4 | 44.4 | 44.4 | |||||||||||||||
Feces | Rat | 0-1 | i.v.c | 12.9 | 2.9 | 5.5 | 2.5 | 1.9 | <0.1 | 12.9 | |||||||||||
Dog | 0-5 | p.o. | 42.5 | 1.1 | 26.2 | 2.8 | 2.1 | 2.1 | 2.9 | 0.7 | 37.9 | ||||||||||
| Human | 0-4 | p.o. | 26.4 | 7.3 | 8.9 | 1.1 |
| 1.6 | 0.9 | 2.9 | 1.6 | 24.3 |