Wild-Type | jvs | |
---|---|---|
Dose (mg/kg) | 10 | 10 |
AUCp.o.(0-240) (mg · min/ml)b | 0.507 ± 0.036 | 1.64 ± 0.27* |
CLtot (ml/min/kg)c | 9.46 ± 1.5 | 3.32 ± 0.25* |
CLrenal,p (ml/min/kg)d | 8.49 ± 0.71 | 2.44 ± 0.33* |
CLsec (ml/min/kg)e | 3.10 ± 0.71 | N.D.f |
GFR (ml/min/kg)g | 7.22 ± 0.49 | 6.18 ± 0.90 |
MRT (min)h | 34.2 ± 18.8 | 81.5 ± 10.1* |
Vdss (l/kg)i | 0.286 ± 0.021 | 0.265 ± 0.025 |
fpj | 0.747 ± 0.028 | 0.767 ± 0.029 |
↵* Significantly different from wild-type mice.
↵ a CER (10 or 50 mg/kg b.wt.) was administered intravenously or orally, respectively, to male mice.
↵ b Area under the plasma concentration curve after oral administration from 0 to 240 min.
↵ c Total clearance.
↵ d Renal clearance with respect to the plasma concentration.
↵ e Renal secretion clearance.
↵ f Not determined because CLrenal,p was lower than fp · GFR.
↵ g Creatinine clearance determined as GFR.
↵ h Mean residence time.
↵ i Steady-state distribution volume.
↵ j Unbound fraction in plasma.